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MN58b

Chemical Structure : MN58b

CAS No.: 203192-01-2

MN58b (MN-58b;MN 58b)

Catalog No.: PC-60866Not For Human Use, Lab Use Only.

MN58b is a potent, selective choline kinase α (ChoKα) inhibitor with IC50 of 1.4 uM, >30-fold selectivity over ChoKβ and does not affect MAPKs, PI3Ks, and other enzymes involved in the regulation of phospholipid metabolism.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

MN58b is a potent, selective choline kinase α (ChoKα) inhibitor with IC50 of 1.4 uM, >30-fold selectivity over ChoKβ and does not affect MAPKs, PI3Ks, and other enzymes involved in the regulation of phospholipid metabolism.
MN58b demonstrates antiproliferative properties against human tumor-derived cell lines (HT29 IC50=0.5 uM) and antitumor activity against human tumor xenografts in vivo.

Physicochemical Properties

M.Wt 640.508
Formula C32H40Br2N4
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

1,1'-((butane-1,4-diylbis(4,1-phenylene))bis(methylene))bis(4-(dimethylamino)pyridin-1-ium) bromide

References

1. Lacal JC, et al. Mol Cancer Ther. 2015 Jan;14(1):31-9.

2. Hernández-Alcoceba R, et al. Cancer Res. 1999 Jul 1;59(13):3112-8.

3. Al-Saffar NM, et al. Cancer Res. 2006 Jan 1;66(1):427-34.

4. Guma M, et al. Ann Rheum Dis. 2015 Jul;74(7):1399-407.

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