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MN714

Chemical Structure : MN714

CAS No.:

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MN714 (MN 714, MN-714)

Catalog No.: PC-21791Not For Human Use, Lab Use Only.

MN714 is a cell-premeable prodrug of MN551 containing a pivaloyloxymethyl (POM) and covalent inhibitor of E3 ligase suppressor of cytokine signaling 2 (SOCS2).

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    MN714 is a cell-premeable prodrug of MN551 containing a pivaloyloxymethyl (POM) and covalent inhibitor of E3 ligase suppressor of cytokine signaling 2 (SOCS2).
    MN714 (1 uM and 10 uM) shows a dose-dependent increase in levels of SOCS2 modification.
    MN714 (10 uM) shows a complete saturation of Cys111 with no detectable levels of unmodified Cys111 in K562 cells.

    Physicochemical Properties

    M.Wt 792.19
    Formula C37H44ClFN3O11P
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    FC1=CC=C(CC(N[C@H](C(NCC2=CC=CC(NC(Cl)=O)=C2)=O)CC3=CC=C(OP(OCOC(C(C)(C)C)=O)(OCOC(C(C)(C)C)=O)=O)C=C3)=O)C=C1

    References

    1. Sarath Ramachandran, et al. Nat Commun. 2023 Oct 10;14(1):6345.

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