Chemical Structure : MPAM-15
CAS No.:
311783-51-4
MPAM-15
(MPAM15)
Catalog No.: PC-26060Not For Human Use, Lab Use Only.
MPAM-15 is a potent, selective, brain penetrant positive allosteric modulator of μ-opioid (MOR) receptor with pEC50 of 9.9, >16-fold selectivity for μOR over δOR, κOR, and NOPR.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
MPAM-15 is a potent, selective, brain penetrant positive allosteric modulator of μ-opioid (MOR) receptor with pEC50 of 9.9, >16-fold selectivity for μOR over δOR, κOR, and NOPR.
MPAM-15 demonstrates 33- and threefold higher PAM cooperativity for DAMGO-induced μOR activation compared to BMS122 and BMS187, respectively.
MPAM-15 also exhibits comparable PAM activity at δOR and κOR.
MPAM-15 allosterically stabilizes the active conformation of μOR.
MPAM-15 enhances morphine-induced antinociception without increasing side effects.
The combination of MPAM-15 (15 or 30 mg/kg) with morphine (5 mg/kg) achieved analgesia equivalent to that of morphine (10 mg/kg) but without inducing comparable respiratory depression or constipation.
Physicochemical Properties
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M.Wt
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450.96
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Formula
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C27H27ClO4
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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9-(5-(4-chlorophenyl)furan-2-yl)-3,3,6,6-tetramethyl-3,4,5,6,7,9-hexahydro-1H-xanthene-1,8(2H)-dione
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References
1. Wang Y, et al. Sci Adv. 2026 Feb 13;12(7):eaea9832.
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