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Chemical Structure : MPI-0479605
CAS No.: 1246529-32-7
Catalog No.: PC-43142Not For Human Use, Lab Use Only.
MPI-0479605 is a potent, selective, ATP competitive inhibitor of Mps1 with IC50 of 1.8 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $148 | In stock | |
| 25 mg | $238 | In stock | |
| 50 mg | $398 | In stock | |
| 100 mg | Get quote |
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MPI-0479605 is a potent, selective, ATP competitive inhibitor of Mps1 with IC50 of 1.8 nM.
MPI-0479605 triggers the time-dependent degradation of both cyclin B and securin, decreases BubR1 phosphorylation in nocodazole-arrested cells, blocks apparent autophosphorylation of Mps1 at threonine 676 in HEK293T cells.
MPI-0479605 impairs spindle assembly checkpoint (SAC), resulting in chromosome segregation defects and aneuploidy, induces p53-p21 pathway in an ATM- and ATR-dependent manner.
MPI-0479605 exhibits cytotoxicity across a broad range of tumor cell lines and antitumor activity in human tumor xenografts.
| M.Wt | 407.512 | |
| Formula | C22H29N7O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: 11 mg/mL |
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| Chemical Name/SMILES |
9H-Purine-2,6-diamine, N6-cyclohexyl-N2-[2-methyl-4-(4-morpholinyl)phenyl]- |
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1. Tardif KD, et al. Mol Cancer Ther. 2011 Dec;10(12):2267-75.
2. Vijay Kumar D, et al. Bioorg Med Chem Lett. 2012 Jul 1;22(13):4377-85.
3. Uitdehaag JCM, et al. J Mol Biol. 2017 Jul 7;429(14):2211-2230.
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