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Chemical Structure : MRIA9
Catalog No.: PC-72723Not For Human Use, Lab Use Only.
MRIA9 is a potent, selective dual SIK/PAK inhibitor, inhibits SIK1/2/3 with cellular IC50 of 586/180/127 nM, respectively.
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MRIA9 is a potent, selective dual SIK/PAK inhibitor, inhibits SIK1/2/3 with cellular IC50 of 586/180/127 nM, respectively.
MRIA9 displays excellent selectivity in scanMAX kinase assay panel of 468 kinases.
MRIA9 sensitizes ovarian cancer cells to treatment with the mitotic agent paclitaxel.
MRIA9-induced inhibition of SIK2 blocks the centrosome disjunction, impairs the centrosome alignment, and causes spindle mispositioning during mitosis.
MRIA9 increases chromosomal instability in ovarian cancer cell lines.
| M.Wt | 495.939 | |
| Formula | C25H23ClFN5O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Tesch R, et al. J Med Chem. 2021 Jun 24;64(12):8142-8160.
2. Raab M, et al. Cancers (Basel). 2021 Jul 21;13(15):3658.
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