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Chemical Structure : MRL-871
Catalog No.: PC-35406Not For Human Use, Lab Use Only.
MRL-871 (MRL871) is a potent, selective inhibitor of RORγt via allosteric inverse agonism, inhibits coactivator binding with IC50 of 7 nM.
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MRL-871 (MRL871) is a potent, selective inhibitor of RORγt via allosteric inverse agonism, inhibits coactivator binding with IC50 of 7 nM.
MRL-871 significantly reduces the IL17a mRNA levels in EL4 murine lymphoblast cell line at 10 uM.
| M.Wt | 444.794 | |
| Formula | C22H12ClF3N2O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Scheepstra M, et al. Nat Commun. 2015 Dec 7;6:8833.
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