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MRS-2365

Chemical Structure : MRS-2365

CAS No.: 436847-09-5

MRS-2365 (MRS2365)

Catalog No.: PC-61410Not For Human Use, Lab Use Only.

A highly potent, selective P2Y1 receptor agonist with EC50 of 1.2 nM.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

A highly potent, selective P2Y1 receptor agonist with EC50 of 1.2 nM; exhibits no agonist activity at the P2Y12 receptor and very low activity at the P2Y13 receptor; induces rapid desensitization of the P2Y1 receptor of human platelets.

Physicochemical Properties

M.Wt 549.28
Formula C13H16N5O9P2SNa3
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

Diphosphoric acid, mono[[(1R,2R,3S,4R,5S)-4-[6-amino-2-(methylthio)-9H-purin-9-yl]-2,3-dihydroxybicyclo[3.1.0]hex-1-yl]methyl] ester (9CI)

References

1. Ravi RG, et al. J Med Chem. 2002 May 9;45(10):2090-100.

2. Chhatriwala M, et al. J Pharmacol Exp Ther. 2004 Dec;311(3):1038-43.

3. Bourdon DM, et al. J Thromb Haemost. 2006 Apr;4(4):861-8.

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