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Chemical Structure : MRS 1477
Catalog No.: PC-60668Not For Human Use, Lab Use Only.
A small molecule positive allosteric modulator of both proton and vanilloid activation of TRPV1 (EC50=21.3 uM).
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A small molecule positive allosteric modulator of both proton and vanilloid activation of TRPV1 (EC50=21.3 uM); increases sensitivity of already sensitized TPRV1 toward capsaicin, does not affect inhibition by capsazepine or ruthenium red and remains effective in potentiating activation by pH in the presence of an orthosteric vanilloid antagonist.
| M.Wt | 389.51 | |
| Formula | C21H27NO4S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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3. Nazıroğlu M, et al. PLoS One. 2017 Jun 22;12(6):e0179950.
4. Roh EJ, et al. Bioorg Med Chem. 2008 Oct 15;16(20):9349-58.
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