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Chemical Structure : MRS2481
Catalog No.: PC-62066Not For Human Use, Lab Use Only.
MRS 2481 is a potent, reversible Aβ42 neurotoxicity inhibitor with ID50 of 500 nM, potently blocks the Aβ calcium channel and protects neurons from Aβ toxicity.
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MRS 2481 is a potent, reversible Aβ42 neurotoxicity inhibitor with ID50 of 500 nM, potently blocks the Aβ calcium channel and protects neurons from Aβ toxicity.
MRS 2481 also is a potent inhibitor of TNFα-induced phosphorylation and proteosomal destruction of IκBα, inhibits both NFκB and AP-1 signaling on the IL-8 promoter (IC50=1.8 uM).
MRS 2481 blocks TNFα-activated phosphorylation of JNK, the c-JUN kinase.
| M.Wt | 420.391 | |
| Formula | C22H30BrNO2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Diaz JC, et al. Proc Natl Acad Sci U S A. 2009 Mar 3;106(9):3348-53.
2. Tchilibon S, et al. Biochem Pharmacol. 2005 Aug 1;70(3):381-93.
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