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Chemical Structure : MRS 2578
Catalog No.: PC-43381Not For Human Use, Lab Use Only.
MRS2578 is a potent, selective P2Y6 receptor antagonist with IC50 of 37 nM (human) and 101 nM (rat).
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MRS2578 is a potent, selective P2Y6 receptor antagonist with IC50 of 37 nM (human) and 101 nM (rat); inhibits the response to 300 nM UDP at the rat P2Y6 receptor expressed in 1321N1 cells in a concentration-dependent manner, with IC50 values of 101 ± 27 nM and 98 ± 11 nM, respectively; does not affect the UTP (100 nM)-induced responses of cells expressing P2Y2 and P2Y4 receptors as well as P2Y1 and P2Y11 receptor; completely blocks the protection by UDP of cells undergoing TNFα-induced apoptosis at 1 uM; bolcks ischemia/reperfusion injury in vivo in mouse skeletal muscle by P2Y6 receptor activation.
| M.Wt | 472.673 | |
| Formula | C20H20N6S4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 80 mg/mL |
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1. Talasila A, et al. Br J Pharmacol. 2009 Sep;158(1):339-53.
2. Mamedova LK, et al. Biochem Pharmacol. 2004 May 1;67(9):1763-70.
3. Wihlborg AK, et al. Circ Res. 2006 Apr 14;98(7):970-6.
4. Mamedova LK, et al. Pharmacol Res. 2008 Sep-Oct;58(3-4):232-9.
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