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Chemical Structure : MRS4654
Catalog No.: PC-20961Not For Human Use, Lab Use Only.
MRS4654 is a potent, selective antagonist of Gi protein-coupled P2Y14 receptor (P2Y14R, GPR105) with IC50 of 15 nM and 18.6 nM for human and rat P2Y14R, respectively.
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MRS4654 is a potent, selective antagonist of Gi protein-coupled P2Y14 receptor (P2Y14R, GPR105) with IC50 of 15 nM and 18.6 nM for human and rat P2Y14R, respectively.
MRS4654 (10 μmol/kg, i.p.) reversed CCI-induced mechano-allodynia in mouse model of neuropathic pain caused by chronic constriction of the sciatic nerve.
| M.Wt | 489.45 | |
| Formula | C28H18F3NO4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Young-Hwan Jung, et al. J Med Chem. 2021 Apr 22;64(8):5099-5122.
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