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MRS4719

Chemical Structure : MRS4719

CAS No.: 2840581-32-8

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MRS4719 (MRS-4719)

Catalog No.: PC-26160Not For Human Use, Lab Use Only.

MRS4719 is a potent, selective P2X4 receptor antagonist with IC50 of 0.5 uM (human P2X4R), selective versus hP2X1R, hP2X2/3R, hP2X3R.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

MRS4719 is a potent, selective P2X4 receptor antagonist with IC50 of 0.5 uM (human P2X4R), selective versus hP2X1R, hP2X2/3R, hP2X3R.
MRS4719 showed neuroprotective and learning- and memory-enhancing activities in a mouse middle cerebral artery occlusion (MCAO) model of ischemic stroke.
MRS4719 also reduced ATP-induced [Ca2+]i influx in primary human monocyte-derived macrophages. 

Physicochemical Properties

M.Wt 504.61
Formula C26H28N6O3S
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

1H-Naphtho[1,2-b][1,4]diazepine-2,4(3H,5H)-dione, 5-[2-(2,5-dihydro-5-thioxo-1,2,4-oxadiazol-3-yl)-4-pyridinyl]-, compd. with N,N-diethylethanamine (1:1)

References

1. Kiran S Toti, et al. J Med Chem. 2022 Oct 27;65(20):13967-13987.

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