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MRS8431

Chemical Structure : MRS8431

CAS No.:

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MRS8431 (MRS-8431)

Catalog No.: PC-26268Not For Human Use, Lab Use Only.

MRS8431 is a specific inhibitor of ABCG2 (breast cancer resistance protein, BCRP) ATPase activity with IC50 of 160 nM, inhibits ABCG2-mediated substrate transport with marginal effects on the activity of P-gp, sensitizes ABCG2-expressing HEK-293-R5 cells to mitoxantrone.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

MRS8431 is a specific inhibitor of ABCG2 (breast cancer resistance protein, BCRP) ATPase activity with IC50 of 160 nM, inhibits ABCG2-mediated substrate transport with marginal effects on the activity of P-gp, sensitizes ABCG2-expressing HEK-293-R5 cells to mitoxantrone.

Physicochemical Properties

M.Wt 708.13
Formula C36H28ClF2N9O3
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
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Solubility

10 mM in DMSO
Chemical Name/SMILES

(1S,2R,3S,4R,5S)-4-(6-((4-(4-(4-Chlorophenyl)-1H-1,2,3-triazol-1-yl)­benzyl)­amino)-2-((3,4-difluorophenyl)­ethynyl)-9H-purin-9-yl)-2,3-dihydroxy-N-methylbicyclo­[3.1.0]­hexane-1-carboxamide

References

1. Murakami M, et al. J Med Chem. 2026 Feb 26;69(4):4945-4968.

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