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Chemical Structure : MRV03-069
Catalog No.: PC-49388Not For Human Use, Lab Use Only.
MRV03-069 is a small molecule compound that potently and specifically inhibit the colibactin-activating peptidase ClbP (IC50=28 nM), inhibits colibactin-associated genotoxicity.
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MRV03-069 is a small molecule compound that potently and specifically inhibit the colibactin-activating peptidase ClbP (IC50=28 nM), inhibits colibactin-associated genotoxicity.
MRV03-069 does not appear to interact with any of the other serine hydrolases.
MRV03-069 engages the ClbP binding pocket, forming a covalent bond with the catalytic serine.
MRV03-069 could reproduce the phenotypes observed in a clbP deletion mutant and block the genotoxic effects of colibactin on eukaryotic cells.
MRV03-069 also inhibits purified ZmaM with similar potency to ClbP in vitro, a ClbP homolog that is proposed to activate the antibiotic zwittermicin.
| M.Wt | 278.115 | |
| Formula | C13H19BN2O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Volpe MR, et al. Nat Chem Biol. 2022 Oct 17. doi: 10.1038/s41589-022-01147-8.
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