Chemical Structure : MS7710
CAS No.:
762201-39-8
MS7710
Catalog No.: PC-24389Not For Human Use, Lab Use Only.
MS7710 is a brain-penetrant HCN channel inhibitor, exhibits potent inhibitory effect on VTA DA Ih currents as compared to Cilobradine, and greater inhibitory effect than Cilobradine on VTA DA firing rate.
Bulk size, bulk discount!
Welcome credit card payment!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
MS7710 is a brain-penetrant HCN channel inhibitor, exhibits potent inhibitory effect on VTA DA Ih currents as compared to Cilobradine, and greater inhibitory effect than Cilobradine on VTA DA firing rate.
MS7710 displays inhibitory effects on Ih currents and firing rate of VTA DA neurons.
MS7710 decreases firing rate and bursting activity in VTA DA neurons of male and female mice.
MS7710 reverses CSDS-induced hyperdopaminergia in male CSDS-susceptible mice.
MS7710 improves CSDS-induced social, reward, and cognitive deficits.
Physicochemical Properties
|
M.Wt
|
452.60
|
|
Formula
|
C27H36N2O4
|
|
Appearance
|
Solid
|
|
CAS No.
|
|
|
Storage
|
- Solide Powder
-
-20°C 12 Months; 4°C 6 Months
|
- In Solvent
-
-80°C 6 Months; -20°C 6 Months
|
|
Shipping
|
|
|
Solubility
|
10 mM in DMSO
|
|
Chemical Name/SMILES
|
(S)-7,8-dimethoxy-3-((1-(3-methoxyphenethyl)piperidin-3-yl)methyl)-1,3,4,5-tetrahydro-2H-benzo[d]azepin-2-one
|
References
1. Emily M Teichman, et al. Mol Psychiatry. 2025 Apr 8. doi: 10.1038/s41380-025-02972-8.
Contact Us
sales@probechem.com
