MSC-4070 | TEAD inhibitor | Probechem Biochemicals

Chemical Structure : MSC-4070

MSC-4070 (MSC4070)

Catalog No.: PC-25992Not For Human Use, Lab Use Only.

MSC-4070 is a selective, brain-penetrant TEAD1/2/4 inhibitor with IC50 of 14 nM in TEAD reporter assays in SK-HEP-1 cells, with selectivity for TEAD1, 2, 4 over TEAD3, has IC50 of 30 nM in NCI-H226 viability assays.

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Biological Activity

Physicochemical Properties

M.Wt	452.45
Formula	C22H24F4N4O2
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	4-ethyl-3-(5-fluoro-2-methyl-6-(((1r,4r)-4-(trifluoromethyl)cyclohexyl)oxy)pyrimidin-4-yl)-1-methyl-1,4-dihydro-5H-pyrrolo[3,2-b]pyridin-5-one

References

1. Timo Heinrich, et al. RSC Med Chem. 2026 Jan 7. doi: 10.1039/d5md00928f.

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MSC-4070 (MSC4070)

Biological Activity

Physicochemical Properties

References

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