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Chemical Structure : MSC-4106
CAS No.: 2738542-58-8
Catalog No.: PC-47086Not For Human Use, Lab Use Only.
MSC-4106 is a potent, in vivo active inhibitor of TEAD transcription factor with IC50 of 4 and 14 nM in SK-HEP1 reporter and NCI-H226 viability assays, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $248 | In stock | |
| 25 mg | $598 | In stock | |
| 100 mg | Get quote | ||
| 250 mg | Get quote | ||
| 1 g | Get quote |
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MSC-4106 is a potent, in vivo active inhibitor of TEAD transcription factor with IC50 of 4 and 14 nM in SK-HEP1 reporter and NCI-H226 viability assays, respectively.
MSC-4106 binds to TEAD P-site.
MSC-4106 exhibits desirable potency, mouse pharmacokinetic properties, and in vivo efficacy.
| M.Wt | 359.308 | |
| Formula | C18H12F3N3O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
2-methyl-8-(4-(trifluoromethyl)phenyl)-2,8-dihydropyrazolo[3,4-b]indole-5-carboxylic acid |
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1. Heinrich T, et al. J Med Chem. 2022 Jun 28. doi: 10.1021/acs.jmedchem.2c00403.
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