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Chemical Structure : MSU-43085
Catalog No.: PC-21545Not For Human Use, Lab Use Only.
MSU-43085 is a potent, orally bioavailable inhibitor of Mycobacterium tuberculosis (Mtb, EC50=120 nM) and M. abscessus survival, targets MmpL3.
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MSU-43085 is a potent, orally bioavailable inhibitor of Mycobacterium tuberculosis (Mtb, EC50=120 nM) and M. abscessus survival, targets MmpL3.
MSU-43085 is ~10-fold higher in potency than the clinically studied MmpL3 inhibitor SQ109 but ~3- to 5-fold lower than NITD-304 and NITD-349.
MSU-43085 exhibits potent growth inhibition of intracellular Mtb with EC50 of 134 nM.
MSU-43085 is potent against NTM species MAB and MAC with MICs of 2.9 and 23 µM against MAB and MAC, respectively.
MSU-43085 is active against drug-resistant Mtb strains.
MSU-43085 (200 mg/kg) is efficacious in an acute model of Mtb infection.
| M.Wt | 342.26 | |
| Formula | C16H21Cl2N3O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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