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Chemical Structure : MT-DADMe-ImmA
CAS No.: 653592-04-2
Catalog No.: PC-42402Not For Human Use, Lab Use Only.
A stable transition state analogue and inhibitor of human 5'-methylthioadenosine phosphorylase (MTAP) with dissociation constant of 86 pM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $192 | In stock | |
| 25 mg | $360 | In stock | |
| 50 mg | $640 | In stock | |
| 100 mg | $1120 | In stock | |
| 500 mg | Get quote |
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A stable transition state analogue and inhibitor of human 5'-methylthioadenosine phosphorylase (MTAP) with dissociation constant of 86 pM; increases cellular 5'-methylthioadenosine (MTA) concentrations, decreases polyamines, and induces apoptosis in head and neck squamous cell carcinoma cell lines.
| M.Wt | 293.38786 | |
| Formula | C13H19N5OS | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO |
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| Chemical Name/SMILES |
3-Pyrrolidinol, 1-[(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]-4-[(methylthio)methyl]-, (3R,4S)- |
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1. Basu I, et al. J Biol Chem. 2007 Jul 20;282(29):21477-86.
2. Guan R, et al. Biochemistry. 2013 Nov 19;52(46):8313-22.
3. Firestone RS, et al. ACS Chem Biol. 2017 Feb 17;12(2):464-473.
4. Singh V, et al. Biochemistry. 2004 Jan 13;43(1):9-18.
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