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Chemical Structure : MTX-216
Catalog No.: PC-49627Not For Human Use, Lab Use Only.
MTX-216 (MTX216) is a dual PI3K/EGFR inhibitor that blocks neurofibromin 1 loss of function (NF1LoF) melanoma cell growth in vitro and in vivo, suppresses the activity of SYK kinase with IC50 of 281 nM.
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MTX-216 (MTX216) is a dual PI3K/EGFR inhibitor that blocks neurofibromin 1 loss of function (NF1LoF) melanoma cell growth in vitro and in vivo, suppresses the activity of SYK kinase with IC50 of 281 nM.
MTX-216 at 1 μmol/L inhibited p-SYK expression in MeWo cells by approximately 50%, reduced p-BLNK levels in IgM-stimulated Ramos cells.
MTX-216 increases NF1LoF melanoma cells sensitivity to both PI3K and MEK inhibitors, suppresses genes that regulate mitochondrial ETC in NF1LoF cells.
MTX-216 effectively suppressed both Ki-67 and p-S6 in NF1LoF melanoma cells, inducing efficacious antitumor responses in these cells.
| M.Wt | 502.35 | |
| Formula | C22H14Cl2FN5O2S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Cara Abecunas, et al. Cancer Res. 2023 Jan 18;83(2):316-331.
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