Welcome to Shanghai Probechem Biochemicals Co Ltd !Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : MU1700
Catalog No.: PC-72012Not For Human Use, Lab Use Only.
MU1700 is a potent, selective ALK1 (ACVRL1) and ALK2 (ACVR1) protein kinase inhibitor with IC50 of 13 and 6 nM, respectively.
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
MU1700 is a potent, selective ALK1 (ACVRL1) and ALK2 (ACVR1) protein kinase inhibitor with IC50 of 13 and 6 nM, respectively.
MU1700 inhibits only ALK1/2/6 and no additional off targets by kinome-wide screening against 369 protein kinases at 1 uM.
MU1700 affects phosphorylation of SMAD1/5/8 that corresponds to BMP branch of signalling wchich is mediated also by ALK1/2 kinases.
MU1700 is suitable chemical probe for in vivo disease models, and has remarkably high brain penetrance (mice, PO, 100 mg/kg).
| M.Wt | 406.489 | |
| Formula | C26H22N4O | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
|
|
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
