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Chemical Structure : MV1035
Catalog No.: PC-38254Not For Human Use, Lab Use Only.
MV1035 (MV-1035) is a novel small molecule that reduce U87 GBM cells migration and invasiveness, targeting m6A demethylase ALKBH5, also inhibits ALKBH2.
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MV1035 (MV-1035) is a novel small molecule that reduce U87 GBM cells migration and invasiveness, targeting m6A demethylase ALKBH5, also inhibits ALKBH2.
MV1035 directly inhibits active recombinant ALKBH5 protein and, consequently, negatively regulates CD73 protein expression without affecting CD73 mRNA transcription.
In PD-GSCs, MV1035 has a synergistic effect with TMZ in reducing cell viability and their ability to form spheres.
MV1035 is able both to reduce the expression of MGMT and to inhibit ALKBH2 activity.
| M.Wt | 258.339 | |
| Formula | C14H14N2OS | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Malacrida A, et al. Bioorg Med Chem. 2020 Feb 15;28(4):115300.
2. Malacrida A, et al. Biology (Basel). 2022 Jan 4;11(1):70.
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