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Chemical Structure : MW05
Catalog No.: PC-20894Not For Human Use, Lab Use Only.
MW05 is a specific inhibitor for DNA damage-induced NF-κB activity, inhibits CLK2 and CLK4 with IC50 of 1400 and 307 nM, does not inhibit CLK3.
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MW05 is a specific inhibitor for DNA damage-induced NF-κB activity, inhibits CLK2 and CLK4 with IC50 of 1400 and 307 nM, does not inhibit CLK3.
MW05 selectively inhibits etoposide-induced p65 nuclear translocation with IC50 of 690 nM, without affecting p65 translocation upon TNFα stimulation.
MW05 potentiates cell killing effects of chemotherapeutic agents, reduces cell viability and increases p53-mediated apoptosis in U2-OS cells.
| M.Wt | 363.42 | |
| Formula | C20H21N5O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Mucka P, et al. Cell Chem Biol. 2023 Jul 15:S2451-9456(23)00205-2.
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