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Chemical Structure : MYCi975
CAS No.: 2289691-01-4
Catalog No.: PC-73127Not For Human Use, Lab Use Only.
MYCi975 (NUCC-0200975) is a close analog of MYCi361 with improved therapeutic index, binds to MYC protein with KD of 2.5 uM, disrupts MYC/MAX complex formation.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $188 | In stock | |
| 10 mg | $298 | In stock | |
| 25 mg | $488 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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MYCi975 (NUCC-0200975) is a close analog of MYCi361 with improved therapeutic index, binds to MYC protein with KD of 2.5 uM, disrupts MYC/MAX complex formation.
MYCi975 (8 uM) enhances MYC degradation and phosphorylation on T58 in treated cells, also directly increases GSK3β-mediated MYC pT58 in the in vitro kinase assay at 6 uM.
MYCi975 inhibits MYC-dependent cancer cell viability and suppresses MYC transcriptional activity.
MYCi975 increases tolerability at significantly higher doses.
MYCi975 exhibits excellent pharmacokinetic profiles following p.o., i.p. or i.v. administration.
MYCi975 (100 mg/kg/day) inhibits tumor growth in MycCaP allografts with no changes in body weight.
MYCi975 synergized with Ara-C with no obvious impact in NSG mice bearing MV-411 AML xenografts.
| M.Wt | 561.31 | |
| Formula | C25H16Cl2F6N2O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
4'-chloro-6-((4-chlorobenzyl)oxy)-3-(1-methyl-3-(trifluoromethyl)-1H-pyrazol-5-yl)-3'-(trifluoromethyl)-[1,1'-biphenyl]-2-ol |
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1. Han H, et al. Cancer Cell. 2019 Nov 11;36(5):483-497.e15.
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