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Chemical Structure : MZ-101
Catalog No.: PC-21680Not For Human Use, Lab Use Only.
MZ-101 is a potent, selective inhibitor of glycogen synthase 1 (GYS1) with IC50 of 41 nM (human GYS1), with no inhibition against GYS2.
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MZ-101 is a potent, selective inhibitor of glycogen synthase 1 (GYS1) with IC50 of 41 nM (human GYS1), with no inhibition against GYS2.
MZ-101 shows similar potency and selectivity of MZ-101 for the mouse isoform of GYS1.
MZ-101 potently and selectively inhibits GYS1 by a noncompetitive mechanism.
MZ-101 reduces glycogen abundance in a dose-dependent manner in fibroblasts from healthy controls and patients with Pompe disease with a mean EC50 of 500 nM.
MZ-101 inhibits glycogen synthesis across species and cell types expressing GYS1, independent of defects in glycogen catabolism.
MZ-101 inhibits GYS1 but not GYS2 de novo glycogen synthesis in WT and Pompe mice.
| M.Wt | 449.53 | |
| Formula | C25H28FN5O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Ullman JC, et al. Sci Transl Med. 2024 Jan 17;16(730):eadf1691.
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