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Madrasin

Chemical Structure : Madrasin

CAS No.: 374913-63-0

Madrasin (DDD-00107587)

Catalog No.: PC-42098Not For Human Use, Lab Use Only.

A small molecule inhibitor of pre-mRNA splicing that interferes with the early stages of spliceosome assembly and stalls spliceosome assembly at the A complex.

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10 mg $72 In stock
25 mg $144 In stock
50 mg $240 In stock
100 mg $400 In stock

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Biological Activity

A small molecule inhibitor of pre-mRNA splicing that interferes with the early stages of spliceosome assembly and stalls spliceosome assembly at the A complex; induces cell cycle arrest, promotes a specific reorganization of subnuclear protein localization, and modulates splicing of multiple pre-mRNAs in both HeLa and HEK293 cells.

Physicochemical Properties

M.Wt 311.3385
Formula C16H17N5O2
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

4(3H)-Pyrimidinone, 2-[(7-methoxy-4-methyl-2-quinazolinyl)amino]-5,6-dimethyl-

References

1. Pawellek A, et al. J Biol Chem. 2014 Dec 12;289(50):34683-98.

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