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Chemical Structure : Maraviroc
CAS No.: 376348-65-1
Catalog No.: PC-21897Not For Human Use, Lab Use Only.
Maraviroc (UK-427857) is a potent, selective and orally bioavailable CCR5 inhibitor with IC50 of 3.3 nM, 7.2 nM and 5.2 nM for MIP-1α, MIP-1β and RANTES binding to cell membrane preparations of CCR5-expressing HEK-293, shows broad-spectrum activity against HIV-1.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $88 | In stock | |
| 25 mg | $148 | In stock | |
| 50 mg | $238 | In stock | |
| 100 mg | $398 | In stock | |
| 200 mg | Get quote |
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Maraviroc (UK-427857) is a potent, selective and orally bioavailable CCR5 inhibitor with IC50 of 3.3 nM, 7.2 nM and 5.2 nM for MIP-1α, MIP-1β and RANTES binding to cell membrane preparations of CCR5-expressing HEK-293, shows broad-spectrum activity against HIV-1.
Maraviroc (UK-427857) shows potent antiviral activity against the 43 primary CCR5-tropic HIV-1 isolates with a geometric mean IC90 of 2.0 nM.
Maraviroc (UK-427857) does not affect CCR5 cell surface levels or associated intracellular signaling.
Maraviroc (UK-427857) has no detectable in vitro cytotoxicity and is highly selective for CCR5, as confirmed against a wide range of receptors and enzymes, including the hERG ion channel.
| M.Wt | 513.68 | |
| Formula | C29H41F2N5O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
4,4-Difluoro-N-((S)-3-((1R,3R,5S)-3-(3-isopropyl-5-methyl-4H-1,2,4-triazol-4-yl)-8-azabicyclo[3.2.1]octan-8-yl)-1-phenylpropyl)cyclohexane-1-carboxamide |
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1. Dorr P, et al. Antimicrob Agents Chemother. 2005 Nov;49(11):4721-32.
2. Wood A, et al. Prog Med Chem. 2005;43:239-71.
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