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Chemical Structure : Marbostat-100
Catalog No.: PC-63292Not For Human Use, Lab Use Only.
Marbostat-100 is a potent, selective HDAC6 inhibitor with Ki of 0.7 nM, displays >200-fold selectivity over HDAC1-5, and HDAC7-10.
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Marbostat-100 is a potent, selective HDAC6 inhibitor with Ki of 0.7 nM, displays >200-fold selectivity over HDAC1-5, and HDAC7-10.
Marbostat-100 is a more selective HDAC6i than previously established well-characterized compounds.
Marbostat-100 is well tolerated by mice and demonstrates in vivo anti-inflammatory activity against collagen type II induced arthritis, represents a most selective known HDAC6i and the possibility for clinical evaluation of a HDAC isoform-specific drug.
| M.Wt | 404.426 | |
| Formula | C22H20N4O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Sellmer A, et al. J Med Chem. 2018 Apr 6. doi: 10.1021/acs.jmedchem.7b01593.
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