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Maribavir

Chemical Structure : Maribavir

CAS No.: 176161-24-3

Maribavir (Benzimidavir, 1263W94)

Catalog No.: PC-38784Not For Human Use, Lab Use Only.

Maribavir (1263W94, Benzimidavir) is a potent and selective inhibitor of human cytomegalovirus (HCMV) replication with IC50 of 0.13 uM against laboratory strain AD169, and 0.03-0.13 uM against 10 clinical HCMV isolates.

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Biological Activity

Maribavir (1263W94, Benzimidavir) is a potent and selective inhibitor of human cytomegalovirus (HCMV) replication with IC50 of 0.13 uM against laboratory strain AD169, and 0.03-0.13 uM against 10 clinical HCMV isolates.
Maribavir (1263W94) is active against viral mutants that are resistant to GCV, CDV, and PFA.
Maribavir is orally bioavailable, and is the first and only antiviral agent that targets and inhibits the pUL97 protein kinase and its natural substrates.

Physicochemical Properties

M.Wt 376.234
Formula C15H19Cl2N3O4
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

(2S,3S,4R,5S)-2-(5,6-dichloro-2-(isopropylamino)-1H-benzo[d]imidazol-1-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol

References

1. Koszalka GW, et al. Antimicrob Agents Chemother. 2002 Aug;46(8):2373-80.

2. Gershburg E, et al. J Virol. 2002 Feb;76(3):998-1003.

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