Chemical Structure : Maxadilan
CAS No.:
135374-80-0
Maxadilan
Catalog No.: PC-27326Not For Human Use, Lab Use Only.
Maxadilan is a potent, specific PACAP-type I receptor (PAC1) agonist, a potent vasodilator peptide and immunomodulator.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
Maxadilan is a potent, specific PACAP-type I receptor (PAC1) agonist, a potent vasodilator peptide and immunomodulator.
Maxadilan induces the accumulation of cAMP only in PACAP type I receptor expressing cells.
Maxadilan binds specifically to the PACAP type I receptor and competes spatially with the binding of PACAP and vice versa.
Physicochemical Properties
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M.Wt
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6865.72
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Formula
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C291H466N86O94S6
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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Cys-Asp-Ala-Thr-Cys-Gln-Phe-Arg-Lys-Ala-Ile-Asp-Asp-Cys-Gln-Lys-Gln-Ala-His-His-Ser-Asn-Val-Leu-Gln-Thr-Ser-Val-Gln-Thr-Thr-Ala-Thr-Phe-Thr-Ser-Met-Asp-Thr-Ser-Gln-Leu-Pro-Gly-Asn-Ser-Val-Phe-Lys-Glu-Cys-Met-Lys-Gln-Lys-Lys-Lys-Glu-Phe-Lys-Ala-NH2 (Disulfide bridge:Cys1-Cys5, Cys14-Cys51)
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References
1. Lerner EA, et al. J Biol Chem. 1991 Jun 15;266(17):11234-6.
2. Tatsuno I, et al. Brain Res. 2001 Jan 19;889(1-2):138-48.
3. Bozza M, et al. Eur J Immunol. 1998 Oct;28(10):3120-7.
4. Hoover DB, et al. J Pharmacol Exp Ther. 2009 Oct;331(1):197-203.
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