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Chemical Structure : Mefuparib hydrochloride
Catalog No.: PC-61949Not For Human Use, Lab Use Only.
Mefuparib hydrochloride is a potent, highly selective, competitive PARP1/2 inhibitor with IC50 of 3.2/1.9 nM, respectively.
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Mefuparib hydrochloride is a potent, highly selective, competitive PARP1/2 inhibitor with IC50 of 3.2/1.9 nM, respectively.
Mefuparib displays >406-fold over other major nuclear PARPs including PARP3, TNKS1, TNKS2 and PARP6.
Mefuparib reduces poly(ADP-ribose) formation, enhances γH2AX levels, induces G2/M arrest and subsequent apoptosis in homologous recombination repair (HR)-deficient cells.
Mefuparib shows potent in vitro and in vivo proliferation and growth inhibition against HR-deficient cancer cells and synergistic sensitization of HR-proficient xenografts to the anticancer drug temozolomide.
| M.Wt | 334.775 | |
| Formula | C17H16ClFN2O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. He JX, et al. Oncotarget. 2017 Jan 17;8(3):4156-4168.
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