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Metoclopramide

Chemical Structure : Metoclopramide

CAS No.: 364-62-5

Metoclopramide

Catalog No.: PC-45204Not For Human Use, Lab Use Only.

Metoclopramide is apotent dopamine D2 receptor antagonist with Ki of 28 nM.

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Biological Activity

Metoclopramide is apotent dopamine D2 receptor antagonist with Ki of 28 nM.
Metoclopramide also is a mixed 5-HT3 receptor antagonist/5-HT4 receptor agonist.
Metoclopramide is commonly used to treat nausea and vomiting caused by chemotherapy.

Physicochemical Properties

M.Wt 299.7964
Formula C14H22ClN3O2
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

DMSO: ≥ 41 mg/mL

Chemical Name/SMILES

Benzamide, 4-amino-5-chloro-N-[2-(diethylamino)ethyl]-2-methoxy-

References

1. Matsui A, et al. J Pharmacol Exp Ther. 1998 Nov;287(2):725-32.

2. Tonini M, et al. Pharmacol Res. 1995 May;31(5):257-60.

3. Bateman DN, et al. Br J Clin Pharmacol. 1978 Nov;6(5):401-7.

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