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Chemical Structure : Miclxin
CAS No.: 2494198-61-5
Catalog No.: PC-38409Not For Human Use, Lab Use Only.
Miclxin (DS37262926) is a small molecule inhibitor of MICOS component MIC60, induces mitochondrial stress response in a mutant β-catenin-dependent manner in β-catenin-mutated HCT116 cells, directly binds to mitochondrial inner membrane complex protein MIC60 (SPR Kd=11.9 uM).
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $228 | In stock | |
| 10 mg | $368 | In stock | |
| 25 mg | $558 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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Miclxin (DS37262926) is a small molecule inhibitor of MICOS component MIC60, induces mitochondrial stress response in a mutant β-catenin-dependent manner in β-catenin-mutated HCT116 cells, directly binds to mitochondrial inner membrane complex protein MIC60 (SPR Kd=11.9 uM).
Miclxin (DS37262926) exhibits selective induction of apoptosis in β-catenin-mutated HCT116 cells, which harbor deletion mutant of Ser45. Mutation at Ser45 of β-catenin is detected not only in colorectal tumor but in hepatocellular, prostate and uterine tumors. Miclxin-mediated MIC60 dysfunction induced mitochondrial stress response, leading to apoptosis-inducing factor (AIF)-dependent apoptosis.
| M.Wt | 441.535 | |
| Formula | C26H27N5O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
7-methoxy-N-(3-methoxybenzyl)-2-(3-(pyridin-3-yl)pyrrolidin-1-yl)quinazolin-4-amine |
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1. Hiroaki Ikeda, et al. ACS Chem Biol. 2020 Aug 21;15(8):2195-2204.
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