Catalog No.: PC-38409Not For Human Use, Lab Use Only.
Miclxin (DS37262926) is a small molecule inhibitor of MICOS component MIC60, induces mitochondrial stress response in a mutant β-catenin-dependent manner in β-catenin-mutated HCT116 cells, directly binds to mitochondrial inner membrane complex protein MIC60 (SPR Kd=11.9 uM).
Miclxin (DS37262926) is a small molecule inhibitor of MICOS component MIC60, induces mitochondrial stress response in a mutant β-catenin-dependent manner in β-catenin-mutated HCT116 cells, directly binds to mitochondrial inner membrane complex protein MIC60 (SPR Kd=11.9 uM).
Miclxin (DS37262926) exhibits selective induction of apoptosis in β-catenin-mutated HCT116 cells, which harbor deletion mutant of Ser45.
Mutation at Ser45 of β-catenin is detected not only in colorectal tumor but in hepatocellular, prostate and uterine tumors.
Miclxin-mediated MIC60 dysfunction induced mitochondrial stress response, leading to apoptosis-inducing factor (AIF)-dependent apoptosis.
