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Min-1

Chemical Structure : Min-1

CAS No.: 415686-18-9

Min-1

Catalog No.: PC-20704Not For Human Use, Lab Use Only.

Min-1 is small molecule that inhibits growth of Gram-positive bacteria by targeting the cell envelope, Min-1 is a novel inhibitor of bacterial growth, reduces cell size in Bacillus subtilis.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

Min-1 is small molecule that inhibits growth of Gram-positive bacteria by targeting the cell envelope, Min-1 is a novel inhibitor of bacterial growth, reduces cell size in Bacillus subtilis.
Min-1 inhibits growth of Gram-positive bacteria and reduces cell length of B. subtilis (MIC=31 uM, B. subtilis JH642 (LB)).
Min-1 disrupts coordination between growth and FtsZ ring assembly independent of known cell size mechanisms.
Min-1 activates the LiaRS stress response, which is sensitive to disruptions in the lipid II cycle and the cell membrane, and also compromises cell membrane integrity.

Physicochemical Properties

M.Wt 336.27
Formula C16H11F3N2O3
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

OC1=CC=C(C2=NNC(C(F)(F)F)=C2OC3=CC=CC=C3)C(O)=C1

References

1. Scott McAuley, et al. ACS Chem Biol. 2019 Apr 19;14(4):688-695.

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