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Chemical Structure : Miridesap
Catalog No.: PC-63132Not For Human Use, Lab Use Only.
Miridesap (Ro 638695.
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Miridesap (Ro 638695;GSK-2315698;CPHPC) is a competitive inhibitor of serum amyloid P component (SAP) binding to amyloid fibrils; crosslinks and dimerizes SAP molecules, leading to their very rapid clearance by the liver, and thus produces a marked depletion of circulating human SAP; Miridesap is a novel therapeutic approach to both systemic amyloidosis and diseases associated with local amyloid, including Alzheimer's disease and type 2 diabetes.
Alzheimer Disease
Phase 2 Clinical
| M.Wt | 340.376 | |
| Formula | C16H24N2O6 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Kolstoe SE, et al. Proc Natl Acad Sci U S A. 2009 May 5;106(18):7619-23.
2. Pepys MB, et al. Nature. 2002 May 16;417(6886):254-9.
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