Mocravimod (KRP-203) | S1P1 agonist | Probechem Biochemicals

Chemical Structure : Mocravimod

Mocravimod (KRP-203, KRP203)

Catalog No.: PC-60049Not For Human Use, Lab Use Only.

Mocravimod (KRP-203) is a synthetic immunosuppressant that functions as a S1P1 receptor agonist.

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Biological Activity

Mocravimod (KRP-203) is a synthetic immunosuppressant that functions as a S1P1 receptor agonist.
Mocravimod (KRP-203) significantly inhibits infiltration of inflammatory cells, expression of endothelin-1 and TGF-beta1, and IgG deposition and eventually attenuates neointimal formation and myocardial fibrosis.
Mocravimod (KRP-203) prolongs graft survival and attenuates chronic rejection in rat skin and heart allografts.

Physicochemical Properties

M.Wt	443.986
Formula	C24H26ClNO3S
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-Amino-2-(2-(2-chloro-4-(3-benzyloxyphenylthio)phenyl)ethyl)-1,3-propanediol

References

1. Shimizu H, et al. Circulation. 2005 Jan 18;111(2):222-9.

2. Takahashi M, et al. Transplant Proc. 2005 Jan-Feb;37(1):143-5.

3. Suzuki C, et al. J Heart Lung Transplant. 2006 Mar;25(3):302-9.

Mocravimod (KRP-203, KRP203)

Biological Activity

Physicochemical Properties

References

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