Monophosphoryl lipid A | TLR4 agonist | Probechem Biochemicals

Chemical Structure : Monophosphoryl lipid A

CAS No.: 1246298-63-4

Monophosphoryl lipid A (MPLA, Glucopyranosyl lipid A)

Catalog No.: PC-28403Not For Human Use, Lab Use Only.

Monophosphoryl lipid A (MPLA) is a nontoxic derivative of lipopolysaccharide (LPS) and TRIF-biased toll-like receptor 4 (TLR4) agonist, enhances vaccine adjuvant effects and promotes Th1-type immune response and immunostimulatory properties.

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Biological Activity

Physicochemical Properties

M.Wt	1763.47
Formula	C96H184N3O22P
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Ammonium (2R,3S,4R,5R,6R)-6-(((2R,3S,4R,5R,6S)-3,6-dihydroxy-5-((R)-3-hydroxytetradecanamido)-4-(((R)-3-hydroxytetradecanoyl)oxy)tetrahydro-2H-pyran-2-yl)methoxy)-2-(hydroxymethyl)-5-((R)-3-(tetradecanoyloxy)tetradecanamido)-4-(((R)-3-(tetradecanoyloxy)tetradecanoyl)oxy)tetrahydro-2H-pyran-3-yl hydrogen phosphate

References

1. Tiberio L, et al. Vaccine. 2004 Mar 29;22(11-12):1515-23.

2. Bevaart L, et al. Cancer Res. 2006 Feb 1;66(3):1261-4.

3. Cekic C, et al. J Biol Chem. 2009 Nov 13;284(46):31982-91.

4. Mata-Haro V, et al. Science. 2007 Jun 15;316(5831):1628-32.

Monophosphoryl lipid A (MPLA, Glucopyranosyl lipid A)

Biological Activity

Physicochemical Properties

References

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