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Chemical Structure : Mortaparib Plus
Catalog No.: PC-49357Not For Human Use, Lab Use Only.
Morataprib Plus is a novel anticancer small molecule that disrupts mortalin-p53 interaction, prevents the interaction of mortalin with p53 resulting in the activation of growth arrest and apoptosis mediated by activation of p21WAF1 or BAX and PUMA signalling, respectively.
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Morataprib Plus is a novel anticancer small molecule that disrupts mortalin-p53 interaction, prevents the interaction of mortalin with p53 resulting in the activation of growth arrest and apoptosis mediated by activation of p21WAF1 or BAX and PUMA signalling, respectively.
MortaparibPlus-induced cytotoxicity to cancer cells is mediated by multiple mechanisms that included the inhibition of PARP1, up-regulation of p73, and also the down-regulation of mortalin and CARF proteins that play critical roles in carcinogenesis.
| M.Wt | 287.326 | |
| Formula | C17H13N5 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Sari AN, et al. Cancers (Basel). 2021 Feb 17;13(4):835.
2. Meidinna HN, et al. Front Cell Dev Biol. 2022 Sep 12;10:918970.
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