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Chemical Structure : Motesanib
CAS No.: 453562-69-1
Catalog No.: PC-42471Not For Human Use, Lab Use Only.
Motesanib (AMG-706) is a potent, orally bioavailable, multikinase inhibitor inhibitor of VEGFR1/2/3, PDGFR and c-Kit with IC50 of 2-6 nM, 84 nM and 8 nM, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 50 mg | $138 | In stock | |
| 100 mg | $218 | In stock | |
| 200 mg | Get quote | ||
| 1 g | Get quote |
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Motesanib (AMG-706) is a potent, orally bioavailable, multikinase inhibitor inhibitor of VEGFR1/2/3, PDGFR and c-Kit with IC50 of 2-6 nM, 84 nM and 8 nM, respectively.
Motesanib (AMG-706) also displays activity against Ret (IC50=59 nM), no activities against EGFR, Src, and p38.
Motesanib (AMG-706) inhibits human endothelial cell proliferation induced by VEGF, but not by bFGF in vitro.
Motesanib (AMG-706) potently inhibits VEGF-induced angiogenesis in the rat models.
| M.Wt | 373.4509 | |
| Formula | C22H23N5O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 30 mg/mL |
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| Chemical Name/SMILES |
3-Pyridinecarboxamide, N-(2,3-dihydro-3,3-dimethyl-1H-indol-6-yl)-2-[(4-pyridinylmethyl)amino]- |
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1. Polverino A, et al. Cancer Res. 2006 Sep 1;66(17):8715-21.
2. Sherman SI, et al. N Engl J Med. 2008 Jul 3;359(1):31-42.
3. Coxon A, et al. Clin Cancer Res. 2009 Jan 1;15(1):110-8.
4. Caenepeel S, et al. J Exp Clin Cancer Res. 2010 Jul 15;29:96.
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