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Chemical Structure : Motixafortide
CAS No.: 664334-36-5
Catalog No.: PC-47505Not For Human Use, Lab Use Only.
Motixafortide (BL-8040, BKT-140, TF-14016) is a 14-residue biostable synthetic peptide, high-affinity CXCR4 antagonist (IC50=1 nM).
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $198 | In stock | |
| 25 mg | $498 | In stock | |
| 100 mg | $988 | In stock | |
| 200 mg | Get quote | ||
| 1 g | Get quote |
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Motixafortide (BL-8040, BKT-140, TF-14016) is a 14-residue biostable synthetic peptide, high-affinity CXCR4 antagonist (IC50=1 nM).
Motixafortide (BL-8040, BKT-140, TF-14016) inhibits CXCL12-mediated migration of human Jurkat cells and mouse splenocyte in a dose-dependent manner in vitro (IC50=0.65 and 0.54 nM, respectively).
Motixafortide (BL-8040, BKT-140, TF-14016) ameliorates severity in collagen-induced arthritis in mice.
| M.Wt | 2159.52 | |
| Formula | C97H144FN33O19S2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 36 mg/mL |
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| Chemical Name/SMILES |
L-Argininamide, N2-(4-fluorobenzoyl)-L-arginyl-L-arginyl-3-(2-naphthalenyl)-L-alanyl-L-cysteinyl-L-tyrosyl-N5-(aminocarbonyl)-L-ornithyl-L-lysyl-D-lysyl-L-prolyl-L-tyrosyl-L-arginyl-N5-(aminocarbonyl)-L-ornithyl-L-cysteinyl-, cyclic (4→13)-disulfide |
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1. Tamamura H, et al. FEBS Lett. 2004 Jul 2;569(1-3):99-104.
2. Peled A, et al. Clin Cancer Res. 2014 Jan 15;20(2):469-79.
3. Beider K, et al. Exp Hematol. 2011 Mar;39(3):282-92.
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