MprB-IN-1 | Mtb MprB inhibitor | Probechem Biochemicals

Chemical Structure : MprB-IN-1

MprB-IN-1 (Compound 7a)

Catalog No.: PC-28698Not For Human Use, Lab Use Only.

MprB-IN-1 (Compound 7a) is a small molecule inhibitor of Mycobacterium tuberculosis (Mtb) histidine kinase MprB, reduces ESX-1-dependent pathogenicity, prevents dissemination of Mtb from the lung to the spleen in mouse model of acute TB infection.

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Biological Activity

MprB-IN-1 (Compound 7a) is a small molecule inhibitor of Mycobacterium tuberculosis (Mtb) histidine kinase MprB, reduces ESX-1-dependent pathogenicity, prevents dissemination of Mtb from the lung to the spleen in mouse model of acute TB infection.

Physicochemical Properties

M.Wt	398.48
Formula	C21H22N2O4S
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	ethyl 2-benzamido-7-((dimethylamino)methyl)-6-hydroxybenzo[b]thiophene-3-carboxylate

References

1. Lobanov V, et al. J Med Chem. 2026 Oct 22;69(20):23968-23990.

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MprB-IN-1 (Compound 7a)

Biological Activity

Physicochemical Properties

References

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