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Chemical Structure : Mps1-IN-1
CAS No.: 1125593-20-5
Catalog No.: PC-43476Not For Human Use, Lab Use Only.
Mps1-IN-1 is a potent, selective, ATP-competitive Mps1 kinase inhibitor with IC50 and Kd of 367 nM and 27 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $88 | In stock | |
| 10 mg | $148 | In stock | |
| 25 mg | $248 | In stock | |
| 50 mg | $398 | In stock | |
| 100 mg | Get quote |
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Mps1-IN-1 is a potent, selective, ATP-competitive Mps1 kinase inhibitor with IC50 and Kd of 367 nM and 27 nM.
Mps1-IN-1 also shows high affinity for ALK and LTK (Kd=21 and 39 nM), but shows little or no inhibition on other 352 member kinases.
Mps1-IN-1 induces checkpoint-mediated mitotic arrest in U2OS cells, disrupts recruitment of Mad2 to kinetochores, and reduces the phosphorylation status of Aurora B at threonine-232 (Thr232), suppresses the proliferative capacity of HCT116 cells.
| M.Wt | 535.66 | |
| Formula | C28H33N5O4S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 39 mg/mL |
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| Chemical Name/SMILES |
4-Piperidinol, 1-[3-methoxy-4-[[4-[[2-[(1-methylethyl)sulfonyl]phenyl]amino]-1H-pyrrolo[2,3-b]pyridin-6-yl]amino]phenyl]- |
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1. Kwiatkowski N, et al. Nat Chem Biol. 2010 May;6(5):359-68.
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