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Chemical Structure : Mps1-IN-3
CAS No.: 1609584-72-6
Catalog No.: PC-43017Not For Human Use, Lab Use Only.
Mps1-IN-3 is a selective and highly potent Mps1 kinase inhibitor with IC50 of 50 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $98 | In stock | |
| 25 mg | $158 | In stock | |
| 50 mg | $258 | In stock | |
| 100 mg | Get quote |
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Mps1-IN-3 is a selective and highly potent Mps1 kinase inhibitor with IC50 of 50 nM.
Mps1-IN-3 causes mitotic aberrancies in glioblastoma cells and, in combination with vincristine, induces mitotic checkpoint override, increases aneuploidy and augmentes cell death.
Mps1-IN-3 sensitizes glioblastoma cells to vincristine in orthotopic mouse models, resulting in prolonged survival without toxicity.
| M.Wt | 537.6339 | |
| Formula | C26H31N7O4S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
4-Piperidinol, 1-[3-methoxy-4-[[6-[[2-[(1-methylethyl)sulfonyl]phenyl]amino]-9H-purin-2-yl]amino]phenyl]- |
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1. Tannous BA, et al. J Natl Cancer Inst. 2013 Sep 4;105(17):1322-31.
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