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Chemical Structure : Mps1 inhibitor 2
CAS No.: 1228817-38-6
Catalog No.: PC-62240Not For Human Use, Lab Use Only.
Mps1 inhibitor 2 (Mps1-IN-2) is a potent, selective Mps1 kinase inhibitor with IC50 of 145 nM, demonstrates >1,000-fold selectivity over a panel of 352 kinases with the major exceptions of Gak and Plk1.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $118 | In stock | |
| 10 mg | $188 | In stock | |
| 25 mg | $328 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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Mps1 inhibitor 2 (Mps1-IN-2) is a potent, selective Mps1 kinase inhibitor with IC50 of 145 nM, demonstrates >1,000-fold selectivity over a panel of 352 kinases with the major exceptions of Gak and Plk1.
Mps1-IN-2 treratment leads to defects in Mad1 and Mad2 establishment at unattached kinetochores, decreases Aurora B kinase activity, premature mitotic exit and gross aneuploidy, without any evidence of centrosome duplication defects; decreases cancer cell viability.
| M.Wt | 480.613 | |
| Formula | C26H36N6O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
9-cyclopentyl-2-(2-ethoxy-4-(4-hydroxypiperidin-1-yl)phenylamino)-5-methyl-8,9-dihydro-5H-pyrimido[5,4-b][1,4]diazepin-6(7H)-one |
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1. Kwiatkowski N, et al. Nat Chem Biol. 2010 May;6(5):359-68.
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