Chemical Structure : Mtb GpsI inhibitor X1
CAS No.:
1085839-24-2
Mtb GpsI inhibitor X1
Catalog No.: PC-24913Not For Human Use, Lab Use Only.
Mtb GpsI inhibitor X1 is a specific small molecule inhibitor of mycobacterial PNPase, guanosine penta-phosphate synthase I (GpsI), with IC50 of 1.95 uM.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
Mtb GpsI inhibitor X1 is a specific small molecule inhibitor of mycobacterial PNPase, guanosine penta-phosphate synthase I (GpsI), with IC50 of 1.95 uM.
X1 functions as a noncompetitive inhibitor of Mtb-GpsI, with dissociation constant Ki of 0.79 uM and 0.95 uM for degradation and synthesis of poly(A).
X1 inhibits Mtb-GpsI but not Synechocystis PNPase in a dose-dependent manner.
X1 exhibits potent bactericidal properties, killing 99% of Mtb within 72 h at MIC concentration of 4.4 mg/l (7.8 μM) and within 48 h at two-fold MIC (15.6 μM).
X1 binds to the conserved phosphate-binding pocket and traps the poly(A) substrate.
Physicochemical Properties
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M.Wt
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563.53
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Formula
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C30H24F3N3O5
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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Cyclopentanecarboxylic acid, 1-[[[4′-[[[2-phenyl-5-(trifluoromethyl)-4-oxazolyl]carbonyl]amino][1,1′-biphenyl]-4-yl]carbonyl]amino]-
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References
1. Griesser T, et al. Nucleic Acids Res. 2025 Jun 6;53(11):gkaf529.
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