Mtb LepB inhibitor 17af

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Chemical Structure : Mtb LepB inhibitor 17af

Catalog No.: PC-25077Not For Human Use, Lab Use Only.

Mtb LepB inhibitor 17af is a potent, small molecule inhibitor of M. tuberculosis type I signal peptidase (LepB) with IC90 of 0.41 uM for LepB under-expressing (LepB-UE) strain of M. tuberculosis, shows IC50 of 1.2 uM against wild-type Mtb.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

Physicochemical Properties

M.Wt	472.49
Formula	C23H19F3N4O2S
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	3-amino-6-(6-methoxypyridin-3-yl)-N-(1-phenylethyl)-4-(trifluoromethyl)thieno[2,3-b]pyridine-2-carboxamide

References

1. Lynde BE, et al. ACS Med Chem Lett. 2025 Jan 3;16(2):241-249.

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