Murepavadin (POL7080) | Antibiotic, MRGPRX2 agonist

Chemical Structure : Murepavadin

CAS No.: 944252-63-5

Murepavadin (POL7080, POL 7080)

Catalog No.: PC-61295Not For Human Use, Lab Use Only.

Murepavadin (POL7080) is a highly potent, specific, macrocycle Pseudomonas antibiotic, activates mast cells via MRGPRX2 and MrgprB2.

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5 mg	$198	In stock
10 mg	$298	In stock
25 mg	$458	In stock
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Biological Activity

Murepavadin (POL7080) is a highly potent, specific, macrocycle Pseudomonas antibiotic, activates mast cells via MRGPRX2 and MrgprB2.

Murepavadin displays antibacterial activity against a broad panel of multi-drug-resistant P. aeruginosa.

Murepavadin induces Ca2+ mobilization, degranulation, chemokine IL-8 and CCL3 production in a human MC line (LAD2 cells) endogenously expressing MRGPRX2.

Murepavadin activates human MCs via MRGPRX2 and murine MCs via MrgprB2 and that MRGPRX2 is resistant to β-arrestin-mediated receptor regulation.

activates mast cells via MRGPRX2 and MrgprB2.

Murepavadin shows potential for the treatment of bacterial infections caused by Pseudomonas aeruginosa.

Physicochemical Properties

M.Wt	1553.837
Formula	C73H112N22O16
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	cyclo[Ala-Ser-D-Pro-Pro-Thr-Trp-Ile-Dab-Orn-D-Dab-Dab-Trp-Dab-Dab]

References

1. Bassetti M, et al. Curr Opin Infect Dis. 2018 Jan 13. doi: 10.1097/QCO.0000000000000438.

Murepavadin (POL7080, POL 7080)

Biological Activity

Physicochemical Properties

References

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