Chemical Structure : Muscarinic antagonist KH-5
CAS No.:
1927018-28-7
Muscarinic antagonist KH-5
Catalog No.: PC-27303Not For Human Use, Lab Use Only.
KH-5 is a M1-preferring long-acting muscarinic antagonist (LAMA), functions as a dualsteric PAM antagonist at the M1 receptor, KH-5 behaves mainly as a competitive antagonist at M2 receptors.
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
KH-5 is a M1-preferring long-acting muscarinic antagonist (LAMA), functions as a dualsteric PAM antagonist at the M1 receptor, KH-5 behaves mainly as a competitive antagonist at M2 receptors.
KH-5 antagonised responses to multiple agonists in a saturable and probe-dependent manner, but does not decrease maximal response to agonists, contradicting simple allosteric antagonism.
KH-5 does not bind to the classical muscarinic allosteric site at the second extracellular loop but interacted with an extracellular vestibule site.
Physicochemical Properties
|
M.Wt
|
473.40
|
|
Formula
|
C21H32INO3
|
|
Appearance
|
Solid
|
|
CAS No.
|
|
|
Storage
|
- Solide Powder
-
-20°C 12 Months; 4°C 6 Months
|
- In Solvent
-
-80°C 6 Months; -20°C 6 Months
|
|
Shipping
|
|
|
Solubility
|
10 mM in DMSO
|
|
Chemical Name/SMILES
|
1-{2-[4-(hexyloxy)benzoyloxy]ethyl}-1-methyl-1,2,3,6-tetrahydropyridin-1-ium iodine
|
References
1. Janoušková-Randáková A, et al. Biomed Pharmacother. 2025 Apr;185:117977.
Contact Us
sales@probechem.com
