Catalog No.: PC-25645Not For Human Use, Lab Use Only.
Myc modulator DL78 is a small molecule Myc modulator and potent antimitotic agent with selective anticancer activity, disrupts Myc and α-tubulin interaction and preferentially targets chromosomally unstable, MYC-overexpressing cancer cells.
Myc modulator DL78 is a small molecule Myc modulator and potent antimitotic agent with selective anticancer activity, disrupts Myc and α-tubulin interaction and preferentially targets chromosomally unstable, MYC-overexpressing cancer cells.
DL78 sensitizes platinum-resistant cells to cisplatin and induces apoptosis following mitotic catastrophe.
High Myc-expressing cancer cells are selectively sensitive to DL78.
DL78 (50 mg/kg IP) significantly decreased overall tumor burden and metastatic spread in NSG mice injected intraperitoneally with OV81.2 cells.
DL78 induces cancer-selective mitotic catastrophe by disrupting Myc's interaction with α-tubulin rather than its transcriptional activity.
