You are here:Home-Chemical Inhibitors & Agonists-Proteasome/Ubiquitin-E3 Ubiquitin Ligase-MyoMed-205
MyoMed-205

Chemical Structure : MyoMed-205

CAS No.: 2614161-13-4

MyoMed-205 (MyoMed205, MyoMed 205)

Catalog No.: PC-38106Not For Human Use, Lab Use Only.

MyoMed-205 is a small molecule that inhibits MuRF1 (TRIM63) activity and MuRF1/MuRF2 expression.

Packing Price Stock Quantity
5 mg $258 In stock
10 mg $398 In stock
25 mg Get quote
50 mg Get quote
100 mg Get quote

Bulk size, bulk discount!

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

MyoMed-205 is a small molecule that inhibits MuRF1 (TRIM63) activity and MuRF1/MuRF2 expression.
MyoMed-205 has improved serum stability when compared with initial lead compound ID#704946.
MyoMed-205 attenuates induction of MuRF1 in tumor stressed muscles. MyoMed-205 also rescues citrate synthase and complex-1 activities in tumor-stressed muscles.
MyoMed-205 attenuates skeletal muscle strength loss in mouse model for type 2 diabetes mellitus (T2DM), with no significant effects on serum glucose.
MuRF1 (muscle-specific RING finger protein-1) is a muscle-specific ubiquitin ligase that regulates muscle catabolism during chronic wasting states, both MuRF1 and MuRF2 participate in glucose and, also, in lipid regulation.

Physicochemical Properties

M.Wt 491.562
Formula C26H25N3O5S
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

4-[[(4-Methyl-2-oxo-2H-1-benzopyran-7-yl)oxy]methyl]-N-[2-[[[(2-thienylmethyl)amino]carbonyl]amino]ethyl]benzamide

References

1. Eva Zaccariotto, et al. J Cachexia Sarcopenia Muscle. 2022 Mar 17.

2. Adams V, et al. Cells. 2020 Oct 11;9(10):2272.

3. Labeit S, et al. Int J Mol Sci. 2021 Feb 23;22(4):2225.

4. Bowen TS, et al. J Cachexia Sarcopenia Muscle. 2017 Dec;8(6):939-953.

Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright

Contact Us sales@probechem.com

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • *Additional Information:

Get Quote

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • Additional Information: